Both Revolution and Advantage Multi are topical. They are also the newest heartworm drugs to come out. I go with the ones that ave been trusted for a long time until they sop working for us.
I agree that sometimes intolerant dogs need topicals. Very thankful my girl does fine with Interceptor (beef flavored soy). She could never have HG Plus because it's beef.
The active ingredient in Advantage Mlti is moxidectin. This was also the main ingredient in Proheart 6, the heart worm injection that was pulled or causing 400+ deaths. It is thought at this wasn't the problem ingredient, but I'm waiting to see how Advantage Mulyi does on other peoples' dogs before trusting it.
A lot of people really like Revolution. I'd talk to your vet about it. I have decided against it because I'm not comfortable with it. There seem to be a lot of reports of ineffect. All of them are ineffective at times, but this one may be especially so. There seem to be more ineffect and or side effect reports to the FDA to (per year) than the others. Maybe it doesn't all absorb if owners bathe too early? Anyway, for whatever reason, I don't like it. My vet doesn't use it much either...
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