With all of the times that my family has moved I can tell you that the first 6 months any where you go are the hardest. But despite those forst 6 months being hard I can also tell you that we've cried everytime we've had to leave (which means we eventually learned to love it).
When my husband and I moved down here to Hartsville, SC (only 1.5 hours from Charlotte) it was his first move ever and our first move together. We've been here 6 months and while it's been "home" for a while we're starting to find out niche here. Your family will come to visit and you'll have holiday and vacations that you can take down to see them. I'm sure that you're parents won't be able to stay away from the grandkids.
The best advice I can give you is to take people up on invitations as often as you can and don't hesitate to ask people to do things with you. You need to let us know when you're heading down and then those of us in the area can get together for dinner or a play date
It will be hard, but I know it will turn out alright for you.
Leah