Frontline, Advantage, and Comfortis are adulticides. They kill adult fleas. They do not kill eggs or stop fleas from reproducing before they die. A growth regulator stops the lifecycle. So you are killing the adults with the adulticide and stopping adults from having baby fleas with the growth regulator. Frontline Plus already has a regulator in it. However, you don't have to use one at all if you don't have a flea problem on your pets.
Dogs don't need an intestinal dewormer monthly for the most part. Heartworms are different. If one of your dogs gets them, the treatment of choices is injections of an arsenic compound. There is an injectable available, but there is a history of major issues with it. The most common would be a monthly pill and there is one spot-on product that doubles as a flea preventative (Advantage Multi). There is also Sentinel which is a heartworm drug plus a growth regulator for fleas (no adulticide, so it doesn't kill the adult fleas, but stops them from reproducing).
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