Maybe the vet can tell you if it's a health issue   OR   an attitude problem.  
 
I also work from home and doted on my fur kids.   In one of her many tempter-tantrums,  Ruby peed on my couch because I wasn't giving her all the attention she wanted.  Attitude problem!!!  After 4 years of trying to find a "happy place" where we could all live together with some sort of normalcy, I had to rehome her. 
Hope you find an answer and cure.