Tino was put on the sam-E, milk thistle combo Denamirin as well as a vitamin E supplement last month so we are hoping that will help a bit too. I couldn't agree with you more about putting a happy, seemingly healthy pup through unnecessary biopsies and intrusive procedures. It seems so cruel, especially after the specialist was convinced at our last ultrasound that he had contracted some type of "environmental" issue thus creating his liver/ kidney issues.
Also, Tino is our little explorer and loves to smell, roll in and walk through all the gunk and junk he can find...his speciality is rolling in fresh bird poop (EWWW!!!!

). I always just chalked it up to him being a curious little boy and then just gave him a good shampoo. It's so crazy to read about lepto and see how easily it is transmitted
Of course we will go in with an open mind and hope for the best, but I feel like this has given me a good insight on a possible reason for his liver enzyme abmormalities and kidney issues. He has already been put through some different blood tests and has been such a trooper. I have called the vet to get all his vaccine records so I can take them with me to the specialist as well...
Thanks for your response, please wish us luck