I always put Sasha's rolled up in a little bit of cheese, chicken, peanut butter, etc. and put it in her food bowl with her other food. She would usually just gobble it up with all the other food without realizing she had taken her meds. This worked good with her heartworm and thyroid pills but I have to admit that she would not touch her antibiotics when she was ill before she passed away. When she stopped refusing something with cheddar cheese ( her favorite) I knew something was seriously wrong. I called my vet and he recommended marshmallow creme but she still refused