I worry about larger dogs since my Angel was "accidentally" killed by my brother's cocker. I would hate to see anything like that happen to anyone else. I am sure every circumstance is different, and there are many folks who have big dogs and little dogs, but I would say take it slow. Keep them both under control and let them get used to each other very slowly, and someone needs to watch them all the time. At any sign of aggression, seperate them immediately.
Good luck, and be careful.
