My breeder stressed not giving lepto to mine. She went so far as to write it on her puppy vaccination card. So she has never received the lepto vaccine.
I thought you might be interested in reading this:
An anaphylactic reaction is the most serious reaction to a vaccine, as it is life-threatening. These reactions are most common when killed vaccines are injected. Although the reaction is relatively rare, immediate action must be taken to save the dog's life. While anaphylactic reactions usually take place shortly after the vaccination, they can occur within 24 hours.
Symptoms include sudden onset of vomiting or seizures, or the dog may simply collapse. Give epinephrine as soon as possible. Veterinarians should have it on-hand and for those who give their own shots, it can be ordered with the vaccines..
Side Effects of Leptospirosis Vaccine for Dogs | DailyPuppy.com
I'm not saying that is what happened to your yorkie. It is simply food for thought. I'm so sorry this has happened. You have taken such good care of her.