[Ellie May]

I agree with you KJC in that all drugs can potentially cause enzyme number changes and/or damage to the liver and/or kidneys because drugs are metabolized to the greatest extent by these organs.

But I've seen nothing that would indicate that vaccines do this to a greater extent. It would also have to be rare because otherwise every vaccinated dog would be walking around with high liver enzymes. There is also nothing indicating that lepto is the worst on the liver or that it increases liver enzymes more than the rest. I guess that goes along with remembering that all drugs have the potential to do strange things to the body and a veterinarian should assess whether or not there is enough benefit before using them. In hte case of most vaccines and for most dogs, it is worth it.

The two to three fold thing is interesting. I'm not so sure that toxins almost always make liver enzymes skyrocket though. This is something I will have a talk with E's vet about when I get a chance because I'm sure she has treated things like this many times.