At 4 years of age I seriously doubt that your girl has Liver Shunt.
Did you have a Urinalysis performed....kidney stones and kidney functions. X-rays for a possible blockage.
I suggest that PM Monolo's Mom.....she may be able to provide you with a information on a med to stimulate your girl's appetite.
You may want to go to the breeder forum, there is a Fading puppy recipe that you may want to attempt to give your girl to keep her energy up. As well as giving her NutriCal. Water intake is a must, whatever it takes get it down her. Try everything you can to entice her, although a bland diet of boiled, boneless, skinless chicken and rice would be best.
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