I wouldn't breed past 4 maybe 5 years. Maybe earlier it all depends on the bitch.
Most of mine don't go into heat but every 9 months or more. My vet said if everything checked out good not to skip. Most my girls if I skip would put 2 years between litters and he said that was more harmful. If I had a girl that went every 6 months now that would be different.
__________________ Melissa 
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