[gemy]

Nomenclature N/N equals normal dog carries no copy of the gene

N/HU dog carries one copy of the gene - will not be affected by disease

HU/HU dog has two copies of the gene is susceptible to bladder stones.formed of urate or uric acid.

Say you have a male sire let's call him Max and you breed him once. Sometime later on you find out he has bladder stones formed of uric acid. You now know that he is a HU/HU.

If you bred him to a N/N female then these offspring will all have one copy of the gene present 100% N/HU. They are all carriers.

If the female in this case was a carrier of the gene herself N/HU then these offspring will have a 50% chance of being HU/HU and a 50% chance of being carriers N/HU.

As you can clearly see it won't take long for this to go through a breed if testing is not done.

Should you breed a carrier to a carrier N/HU to N/HU the stats for this come out as follows 25% N/N 50% N/HU 25% HU/HU

So what to do as a guardian of this breed? Be you a breeder or a lover of Yorkies


In my opinion if you have a pet that does form these stones, please get back to the breeder you bought from, and inform them of this condition. Also if you can, inform both sides of the equation, ie: the sire's owners as well as the bitch's.

As a breeder; a conservative approach would be to test your breeding stock to see just what you have in terms of this gene. If you have a carrier, then I would want to have the bitch/sire I wish to breed with checked out for their status. Remember if you breed a carrier to a carrier you will produce 25% puppies which will have hyperuricosia, and 50% carriers.Or another way of looking at this is 3/4 of the litter have either one or two copies of the gene present.

An affected dog quite simply shouldn't be bred.