Iso (and I would guess Sevo) are are not really dosed like typical drugs. I've watched Iso being given many times and not once have I heard there is one dose for small dogs and one for large. It is a certain % concentration (probably around 1.5 - 2.5) given with oxygen. They can turn the machine up as needed if the pup starts to shows signs of awareness. So to answer your question, I'd be uncomfortable with that answer.
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