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Anaic · 10-12-2010, 12:32 PM

[QUOTE=karab;3297080]What is the Anipryl for? Confusion?

ANIPRYL®
(selegiline hydrochloride, L-deprenyl hydrochloride)
Tablet

Description
* Prescription medication for treatment of canine Cognitive Dysfunction Syndrome (CDS), an age-related neurologic syndrome characterized by various cognitive impairments such as disorientation, reduced social interaction, changes in sleep and activity patterns, and loss of housetraining.
* Daily treatment for chronic use.
Approved Use
ANIPRYL® (selegiline hydrochloride, L-deprenyl hydrochloride) is approved for:
* Control of clinical signs associated with canine CDS.
* Control of clinical signs of uncomplicated canine pituitary-dependent hyperadrenocorticism (PDH).

Key Features
* First and only product approved for the treatment of CDS.
* First and only product approved for control of uncomplicated PDH.
* No loading dose, induction phase or extensive endocrine monitoring required.
* Works at the hypothalamic-pituitary level to normalize dopamine levels without causing adrenal toxicity or insufficiency.
* No specific laboratory tests required for treatment.
* Available in multiple dosage sizes.
* Can be given with food.
Packaging
Five tablet strengths in blister packs of 30 tablets each: 2 mg, 5 mg, 10 mg, 15 mg and 30 mg.

Dosage and Administration
* CDS – 0.5–1.0 mg/kg once daily, preferably administered in the morning. Initially, dogs should be dosed to the nearest whole tablet. Adjustments should then be made based on response and tolerance to the drug.
* PDH – 1.0 mg/kg once daily, preferably administered in the morning. If no improvement is observed after 2 months of therapy, dosage may be increased to a maximum of 2.0 mg/kg once daily. If no improvement is seen after 1 month at the higher dose or if at any time clinical signs progress, the dog should be re-evaluated.

Precautions
* For use in dogs only.
* For use by or on the order of a licensed veterinarian.
* Do not administer at doses exceeding recommended levels (0.5–2.0 mg/kg/day).
* In studies, the common side effects were vomiting, diarrhea or changes in behavior. Most side effects were mild to moderate.
* In a placebo-controlled study, most of the adverse events in dogs treated with Anipryl were also observed in placebo-treated dogs, although the rates in placebo-treated dogs were lower.
* Concurrent use of Anipryl with ephedrine, MAO inhibitors or potential MAO inhibitors, such as amitraz, is not recommended.
* As dogs grow older, they are likely to experience more health problems. Senior dogs should be observed more closely because changes in normal appearance, activity and behavior all can be signs that veterinary attention may be needed.
* Consult your veterinarian before using Anipryl with other medications or with tick collars.
* Keep out of reach of children.

10-12-2010, 12:32 PM	#244
Anaic Donating Senior Yorkie Talker Join Date: Jul 2007 Location: parma ohio Posts: 166	anipryl [QUOTE=karab;3297080]What is the Anipryl for? Confusion? ANIPRYL® (selegiline hydrochloride, L-deprenyl hydrochloride) Tablet Description * Prescription medication for treatment of canine Cognitive Dysfunction Syndrome (CDS), an age-related neurologic syndrome characterized by various cognitive impairments such as disorientation, reduced social interaction, changes in sleep and activity patterns, and loss of housetraining. * Daily treatment for chronic use. Approved Use ANIPRYL® (selegiline hydrochloride, L-deprenyl hydrochloride) is approved for: * Control of clinical signs associated with canine CDS. * Control of clinical signs of uncomplicated canine pituitary-dependent hyperadrenocorticism (PDH). Key Features * First and only product approved for the treatment of CDS. * First and only product approved for control of uncomplicated PDH. * No loading dose, induction phase or extensive endocrine monitoring required. * Works at the hypothalamic-pituitary level to normalize dopamine levels without causing adrenal toxicity or insufficiency. * No specific laboratory tests required for treatment. * Available in multiple dosage sizes. * Can be given with food. Packaging Five tablet strengths in blister packs of 30 tablets each: 2 mg, 5 mg, 10 mg, 15 mg and 30 mg. Dosage and Administration * CDS – 0.5–1.0 mg/kg once daily, preferably administered in the morning. Initially, dogs should be dosed to the nearest whole tablet. Adjustments should then be made based on response and tolerance to the drug. * PDH – 1.0 mg/kg once daily, preferably administered in the morning. If no improvement is observed after 2 months of therapy, dosage may be increased to a maximum of 2.0 mg/kg once daily. If no improvement is seen after 1 month at the higher dose or if at any time clinical signs progress, the dog should be re-evaluated. Precautions * For use in dogs only. * For use by or on the order of a licensed veterinarian. * Do not administer at doses exceeding recommended levels (0.5–2.0 mg/kg/day). * In studies, the common side effects were vomiting, diarrhea or changes in behavior. Most side effects were mild to moderate. * In a placebo-controlled study, most of the adverse events in dogs treated with Anipryl were also observed in placebo-treated dogs, although the rates in placebo-treated dogs were lower. * Concurrent use of Anipryl with ephedrine, MAO inhibitors or potential MAO inhibitors, such as amitraz, is not recommended. * As dogs grow older, they are likely to experience more health problems. Senior dogs should be observed more closely because changes in normal appearance, activity and behavior all can be signs that veterinary attention may be needed. * Consult your veterinarian before using Anipryl with other medications or with tick collars. * Keep out of reach of children. __________________ Anne furmommy to Shelby and Willow our little doll, Mooshe, Luka, Cocoa