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Originally Posted by jp4m2  I'm assuming since Mabel had three sets of vaccines she is about 16-18 weeks old. And assuming the pup was not vaccinated when she was ill, stressed or weak and the vaccine was handled properly in storage. Maternal antibody interference is the most common cause of vaccine failure. She should be clear to go out since it has been two weeks.......
Vaccines do not stimulate immunity immediately after they are administered. Once a vaccine is administered, the antigens must be recognized, responded to, and remembered by the immune system. In most puppies, disease protection does not begin until five days post vaccination. Full protection from a vaccine usually takes up to fourteen days....... Peak rabies antibody titers are reached 28 days after the initial rabies vaccination, and the animal is considered immunized at that time. |
Excellent post! If vaccinations are started too early (before 9 weeks or so), the antibodies your puppy got from nursing will block the effectiveness. In that case, the puppy needs another round to protect him.
In one study of a cross section of different puppies the age at which they were able to respond to a vaccine and develop protection covered a wide period of time. At six weeks of age, 25% of the puppies could be immunized. At 9 weeks of age, 40% of the puppies were able to respond to the vaccine. The number increased to 60% by 16 weeks, and by 18 weeks of age, 95% of the puppies could be immunized. Parvovirus: Serious Diarrhea in Puppies & Dogs