We have a Zain, our 115 pound pyrenees mix, Darwin who is our 7 pound Yorkie and we adopted Mabel this summer who is still 2 pounds at 18 weeks. We picked her up when we were camping so the meeting was done on neutral territory. That was back in early August. Things are great - Zain is very gentle with Mabel, she LOVES Zain and she and Darwin are the best of friends. If anything, it's Mabel that attacks Darwin which is really funny to watch. They race around the house, Mabel totally chasing Darwin and Darwin not too sure where to hide - fun, fun, fun!!