I believe diagnosis is usually between 6 and 12 months is the norm, but can be as late as 16 months depending on the initial severity of the disease and quickness of progression.
It also like what is out there right now on liver shunts says it may be genetic but other factors can cause it. One being trauma to the area, lack of blood flow due to maternal factors, etc. But the general consensus is that in purebred dogs, especially Yorkies, they are both genetic and parents of an affected pup should be spayed and neutered, as should all of their offspring IMO.
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