Traditional vets will recommend Benadryl all the time and that's basically it - and all they seem to know. My problem with Benadryl is that it supresses the immune system, so personally I choose to use alternative holistic remedies instead and have had great success. You need to use what you feel comfortable with. Some people have success with Rescue Remedy and others don't - and that goes for other products and/or Benadryl as well. For anxiety reducing I personally like a product called Rara Avis Chill Out Oil.