My dad has an RV and travels with his 2 dogs often. Jackson went once -- they do great.
We just fill up their water bowls before we leave and leave them out as we drive, as if we were at home. Typically, while dad is driving, the dogs just lay on the couch or look out the window as we drive like any car ride. Don't use potty pads here so don't know what people do about that. Farthest they've traveled is around 13hrs and they usually just stop twice or so for a potty break. RV'ing is fun! You've got everything with you while you're driving, it's very convenient! They stay in their RV though and go camping, etc so no hotels, the RV is their 'home' for a few days. We have 3 expens we line all around the RV as a 'fence' for the dogs!