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Female dogs are slightly more affected than male dogs, and small breed and specifically poodles appear to be more commonly affected.

The location of GME may occur either in the meninges (menigo), brain (encephalo), or the spinal cord (myelitis). It may affect one, two, or all three components of the CNS.
What to Watch For

Clinical signs are variable and reflect the area of the CNS affected. If GME affects the forebrain, clinical signs could involve:

Blindness

Seizures

Altered mental status

Pacing

Circling

Head pressing

Stumbling with a nearly normal gait

If GME affects the hindbrain (brainstem +/- cerebellum), clinical signs may include:


Falling

Rolling

Inability to blink

Facial paralysis

Voice change

Mental depression

Tremors

Spastic gait and broad based stance

Spinal cord involvement of GME may include such signs as:


Fever

Spinal pain

Weakness or paralysis in one, two, or all four legs

If the forebrain is primarily affected, response to immunosuppressive corticosteroids may be prolonged or rarely curative. If the hindbrain or spinal cord is primarily affected, drug therapy is less successful for complete or long-lasting improvement.

The onset of GME is usually acute with a slowly, insidious progression over one to two months