Those panties will not keep them apart, they will need to be in separate rooms. Of course, you could always get them neutered and spayed, then it won't be an issue any longer. I can't imagine how difficult it would be for your Mr. Darcy, smelling all of those pheromones and not be able to get what he wants. You are going to have one crazy male on your hands, and he'll probably damage doors/gates/whatever you are using to try and separate them, just trying to get to her.
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