REVOLUTION.Stiff hair,clumping of hair,hair discoloration,or a slight powdery residue may be
observed at the treatment site in some animals.These effects are temporary and do not affect the
safety or ffectiveness of he roduct.iscard mpty ubes n your ordinary household refuse.
Flea ontrol n Dogs nd ats
For the prevention and control of flea infestations,REVOLUTION should be administered at monthly
intervals throughout the flea season,starting one month before fleas become active.In controlled
laboratory studies >98%of fleas were killed within 36 hours.Results of clinical field studies using
REVOLUTION monthly demonstrated >990% control of flea infestations within 30 days of the first dose.
Dogs and cats treated with REVOLUTION,including those with pre-existing flea allergy dermatitis,
showed improvement in clinical signs associated with fleas as a direct result of eliminating the fleas
from he nimals nd heir nvironment.
If the dog or cat is already infested with fleas when the first dose of REVOLUTION is administered,
adult fleas on the animal are killed and no viable fleas hatch from eggs after the first administration.
However,an environmental infestation of fleas may persist for a short time after beginning treatment
with EVOLUTION because of he mergence f adult fleas rom pupae.
Heartworm Prevention in ogs and Cats
For the prevention of heartworm disease, REVOLUTION must be administered on a monthly basis.
REVOLUTION may be administered year-round or at least within one month after the animal ’s first
exposure to mosquitoes and monthly thereafter until the end of the mosquito season.The final dose
must be given within one month after the last exposure to mosquitoes.If a dose is missed and a
monthly interval between dosing is exceeded then immediate administration of REVOLUTION and
resumption of monthly dosing will minimize the opportunity for the development of adult heartworms.
When replacing another heartworm preventive product in a heartworm disease prevention program,the
first ose of EVOLUTION must be iven ithin a month of he ast dose f the former medication.
Selamectin, the active ingredient in REVOLUTION, is a macrocyclic lactone compound.These com-
pounds effectively prevent the development of adult heartworms when administered to dogs and cats
within one month of exposure to infective (LL Dirofilaria immitis larvae.Efficacy of macrocyclic lactones
decreases below 100% in dogs, however, if first administered >22 months after exposure to infective larvae.
Thus,in heartworm endemic regions,delaying initiation of heartworm prevention using REVOLUTION
beyond 2 months of first exposure to infective larvae (e.g.,starting puppies and kittens at >8 weeks
of age),or gaps of >2 months in the administration of REVOLUTION during periods of heartworm
transmission,increases the risk of the animal acquiring heartworms.Animals with unknown heartworm
history that test negative for heartworms prior to the initiation of REVOLUTION may be harboring
pre-patent infections at the time REVOLUTION was started.Testing such animals 3-4 months after
initiation f REVOLUTION would e necessary to onfirm their negative heartworm status.
At the discretion of the veterinarian, cats ¡Ý6 months of age may be tested to determine the presence
of existing heartworm infections before beginning treatment with REVOLUTION.Cats already infected
with dult eartworms an e given EVOLUTION monthly to revent further nfections.
Ear Mite Treatment n Dogs nd ats
For the treatment of ear mite (OO cynotis) infestations in dogs and cats, REVOLUTION should be adminis-
tered once as a single topical dose.A second monthly dose may be required in some dogs.Monthly
use of REVOLUTION will control any subsequent ear mite infestations.In the clinical field trials ears
were not cleaned,and many animals still had debris in their ears after the second dose.Cleansing of
the infested ears s recommended to emove the debris.
Sarcoptic ange Treatment n Dogs
For the treatment of sarcoptic mange (SS scabiei) in dogs,REVOLUTION should be administered once
as a single topical dose.A second monthly dose may be required in some dogs.Monthly use of
REVOLUTION will control any subsequent sarcoptic mange mite infestations.Because of the difficulty in
finding sarcoptic mange mites on skin scrapings, effectiveness assessments also were based on reso-
lution of clinical signs.Resolution of the pruritus associated with the mite infestations was observed in
approximately 50%of the dogs 30 days after the first treatment and in approximately 90%of the dogs
30 ays fter he econd monthly treatment.
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