ADVERSE REACTIONS:
Pre-approval linical trials:
Following treatment with REVOLUTION, transient localized alopecia with or without inflammation at
or near the site of application was observed in approximately 1%of 691 treated cats.Other signs
observed rarely (¡Ü0.5%of 1743 treated cats and dogs)included vomiting,loose stool or diarrhea with
or ithout lood, norexia, ethargy, alivation, achypnea, nd uscle tremors.
Post-approval xperience:
In addition to the aforementioned clinical signs that were reported in pre-approval clinical trials,there
have been reports of pruritus,urticaria,erythema,ataxia,fever,and rare reports of death.There have
also een rare reports f seizures n dogs see WARNINGS).
DOSAGE:
The recommended minimum ose is .77 mg elamectin per pound (66 mg/kkg) f body eight.
Administer the entire contents of a single dose tube (oor two tubes used in combination for dogs
weighing over 130 pounds) of REVOLUTION topically in accordance with the following tables.(ssee
ADMINISTRATION for he ecommended reatment ntervals).
Cats lb)Package color mg er ube
Potency
(mmg/mmL)
Administered
volume (mmL)
Up o 5 Mauve 15 g 60 0.25
5.1–15 Blue 45 g 60 0.75
For ats over 5 lbs use the appropriate ombination f tubes.
Dogs lb)Package color mg er ube
Potency
(mmg/mmL)
Administered
volume (mmL)
Up o 5 Mauve 15 g 60 0.25
5.1–10 Purple 30 g 120 0.25
10.11–20 Brown 60 g 120 0.5
20.11–40 Red 120 mg 120 1.0
40.11–85 Teal 240 mg 120 2.0
85.11–130 Plum 360 mg 120 3.0
For ogs over 30 bs se he ppropriate ombination f tubes.
Recommended for se n dogs eeks f age and older and in ats 8 weeks f age and older.
ADMINISTRATION:
A veterinarian or veterinary technician should demonstrate or instruct the pet owner regarding the
appropriate echnique or pplying REVOLUTION topically to ogs and cats rior to rst use.
Firmly press the cap down to puncture the seal on the REVOLUTION tube;a clicking sound will con-
firm that the cap has successfully punctured the seal.Remove the cap and check to ensure that the
tip of the tube is open.To administer the product,part the hair on the back of the animal at the base of
the neck in front of the shoulder blades until the skin is visible.Place the tip of the tube on the skin and
squeeze the tube 3 or 4 times to empty its entire contents directly onto the skin in one spot.Keeping
the tube squeezed,drag it away from the liquid and lift to remove.Check the tube to ensure that it is
empty.o not massage the product into he kin. ue o alcohol content, o not apply to roken kin.
Avoid contact between the product and fingers.Do not apply when the haircoat is wet.Bathing
or shampooing the animal 2 or more hours after treatment will not reduce the effectiveness of
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