I'm really sorry your Missy is not doing well.....It really angers me when I see this sort of thing happening....You would think the vet would now better than to ever administer a polyvalent vaccine (combo)......These are very risky for eliciting an adverse reaction, especially for small dogs as you can see from this study........
A two-year study of vaccine reactions (from data gathered at 360 Banfield clinics in 2002 and 2003) concluded: “Young adult small-breed neutered dogs that received multiple vaccines per office visit were at greatest risk of a VAAE [Vaccine Associated Adverse Event] within 72 hours after vaccination.”
The reaction rate increased significantly as body weight decreased. That is, small dogs were at greatest risk for a reaction. Risk for dogs weighing 11 pounds or less was 4 times greater than the risk for dogs weighing 99+ pounds. Medium-sized dogs also had increased risk over larger dogs. I have always been shocked that a Chihuahua puppy and an adult Great Dane are given the same dose shot: 1 mL. They get the same volume of virus or bacteria plus the same volume of adjuvants (boosting agents like aluminum), preservatives (like mercury), antibiotics, stabilizers and foreign tissue cultures (like fetal calf serum). All these ingredients are known to cause vaccine reactions.
Also these combo vaccines have components that are unnecessary, when multiple viruses and/or bacterias are administered all at once they will interfere with each other, resulting in neutralization or cancellation, therefore it will have a less than desirable result.
You may want to think about insisting this reaction be put in Missy's medical records it might be useful for an exemption in the future. Once a dog has a reaction the chances of another one is increased with other vaccines.....
Personally my own dogs are done with vaccines. After all of the research that I have done, too many respectable researchers have proven that boosters are useless and far more damaging.....
I hope Missy is feeling better soon.....