I have been using the plaque-off powder for about 3 - 4 months and have seen a huge improvement. It does take time though to start to see improvement. I bought Petzlife Gel, no way would Maddie let me get that in her mouth!!! I try to brush but don't have much luck. I do better putting the toothpaste of the brush and just letting her chew on the bristles while I hold it. Do you think that is doing any good? One would think a grown woman could hold a 7lb dog and brush it's teeth, but we all know that's not as easy as it sounds!!!