They are extremely fragile. My girl is 3 and 3/4 lbs and broke her leg when she was just 4 months old. All she did was jump from only a few inches off of the ground and fell on her elbow. On that note, they are also quite expensive to fix because of their small size they must see a specialist. One broken leg = 3,500 in vet bills. Their little bones are so small that they break quite easily. You have to be really careful about where you walk, and shutting doors etc. Just one small accident can be fatal to these little ones. The other issue is...they don't really KNOW that they are small dogs, so they aren't very careful. I have been diligent about teaching Missy NOT to jump. She isn't allowed to do stairs, curbs, couches, beds etc. If children want to hold her, they must sit on the floor with her in their lap. Only my closest friends can hold Missy, and I don't trust other dogs around her either.
Anyways, they do take alot more care, but they are really fun, cute, and portable when they are tiny. Little dogs with big personalities for sure!