[jp4m2]

Originally Posted by RachelandSadie

Anyone else using the new stuff Banfield is offering called First Shield Trio?

It has dinotefuran, pyriproxyfen, and permethrin in it!

Please let me know if you use it, have heard of it, have good or bad experiences with it.

Thanks,
Rachel

I don't have anything on the specific product your using.......All I have is some info on Permethrin and pyriproxyfen.......


Permethrin is a neurotoxin insecticide.Permethrins are synthetic pyrethroids that are more stable and last longer. It works by disrupting the nervous system of insects, killing by contact or ingestion. The EPA classifies it as a carcinogen ,it causes lung cancer and liver tumors in mice. Permethrin is indicated as a possible carcinogen by the EPA, causing liver enlargement and cancers in lab. mammals. It is embryotoxic in rabbits, and causes liver damage in mice.

"Pyrethroid toxicity targets nerve and muscle cells in pets, according to a study published in The Veterinary Journal in June 2008. The study found that dermal exposure by application to the skin or coat is the most common route of toxic exposure, potentially causing hyperexcitability, tremors, profuse salivation, and seizures. The seizures can result in brain damage or, less frequently, death.
The EPA approved the company's pyrethroid spot on treatments just as it has approved all spot on treatments, but the agency has a history of approving pet products in the past only to pull them from the market later

Carcinogen: liver and lung tumors
Organ damage: kidney enlargement, changes in the lung
Neurotoxin: tremors, incoordination, elevated body temp. increased agressive behavior, learning disruption
Reproductive: fertility affected
Autoimmune: bone marow changes in lab. animals

But they are also linked to thousands of reported pet poisonings, and they have stirred the ire of pet owners, the concern of veterinarians, and the attention of regulatory agencies.
At least 1,600 pet deaths related to spot on treatments with pyrethroids were reported to the EPA over the last five years, according to an analysis of EPA pesticide incident exposure data by the Center for Public Integrity. That is about double the number of reported fatalities tied to similar treatments without pyrethroids, such as Frontline and Advantage -- although these products also have critics.
Pyrethroid spot ons also account for more than half of "major" pesticide pet reactions reported to EPA over the last five years -- that is, those incidents involving serious medical reactions such as brain damage, heart attacks, and violent seizures. In contrast, non-pyrethroid spot on treatments accounted for only about 6 percent of all major incidents.

Pyriproxyfen An active: sterilizer
Reproductive:reduced weight gain, toxicity to pups





Long term studies, needed to understand the chronic effects of the pesticides, are few and far between by comparison. Chronic diseases such as cancer,immune suppression, developmental or reproductive damage and DNA damage can take months or years to manifest. The cumulative effect and potential damage from continued use of one specific pesticide product or multiple products over a dog's lifetime is unknown. Cumulative effects of chemicals in products are not required to be tested by the EPA before the product is made commercially available.