With two beloved Yorkies in the house, when my daughter wanted to back home and bring her 10 year old Pittie, I was really-really afraid. She assured me that Nitro was a gentle beastie, but ...
He has been amazing. A true gentle giant. He puts up with more stuff from those little dogs than ANY beast should have to, but has never done anything more than give them a warning bark. If that didn't work, he simply removed himself to a bed or other "higher" piece of furniture where he could relax without them pesterin' him.
In this instance, it worked. But he was bottle fed from the time he was only 3 weeks old and truly thinks he's more human than dog

. He has been very gentle with them ... VERY.