Is it possible she has a UTI? That's often the cause when fully trained dogs suddenly start going everywhere, esp. females.
If she gets a clean bill of health from the vet, I would go back to the basics. Get out her crate, keep both eyes on her when she's out of it, etc. After being trained for four years, I'm sure she will remember what to do after a week or two.
She is gorgeous, by the way!
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