OMGoodness! I wish I had advice to give you. I would be super scared for your three-year-old and how terrifying it must be for your two-year-old as well. I guess if it were me, my top priority would be to keep him safe from her. I would not have her sleep with me because I feel like that could be more dominant than her brothers who are presumably not sleeping with you. Please just take what I said as just what I think I might do if I were in this situation. I do not have experience with this and I'm unsure if my suggestion is a good one or not. I would also seek out a trainer--or behaviorist to try to figure out why your girl is acting out. If they are like skinkids then biting and aggression usually doesn't just stop unless the issue that is upsetting them is addressed. The only thing I can offer you is my support and hope that this gets better really soon.