[scrapindee]

So this is posted on their website and is Totally Untrue????

Health issues covered in your DNA Parentage Profiling

Testing to make sure we never have a problem with these health issues in the Biewer Terrier. Once again we are able to take advantage of what science has to offer and put together the best, healthiest breeding program possible.

Neuronal Ceroid Lipofuscinosis ~ (NCL) is a hereditary, progressive, disease in dogs and humans, which commonly leads to blindness and other neurologic problems and can lead to premature death.

Globoid Cell Leukodystrophy ~ Globoid cell leukodystrophy or Krabbe disease is a severe, autosomal recessive disorder resulting from a deficiency of galactocerebrosidase (GALC) activity whereby the white matter is degenerated.

Cystinuria ~ is an inherited disorder caused by a defective transport of the amino acid cystine in the kidney tubules.

Phosphofructokinase Deficiency ~ Canine (PFK) is an autosomal recessive genetic disease which prevents the metabolism of glucose into available energy resulting in exercise intolerance and muscle disease in Cocker Spaniels. PFK deficiency also destroys red blood cells in affected dogs, leading to anemia.

Cone Degeneration ~ This condition is known by many names; day blindness, hemeralopia and cone degeneration - to name a few. These names all describe the same condition, a hereditary visual problem related to intense light.


Retinal Dystrophy ~ During inherited retinal dystrophy in Irish Setter dogs, decreased activity of cGMP phosphodiesterase (PDE) results in high cGMP levels and retinal degeneration (1-3). This defect could be in PDE itself, or in its interactions with other proteins of the rod outer segment.

Severe Combined Immunodeficiency (SCID) ~ SCID is the most severe of the inherited immunodeficiency disorders. As the name implies, there is defective development of all components of the immune system. Pups are affected at a very young age, and are susceptible to a variety of infections. How is severe combined immunodeficiency inherited? This is an X-linked recessive trait. This means only males are clinically affected. However females can carry the trait and there is a 50% chance they will pass it to their male offspring.

Congenital Hypothyroidism / Goiter ~ Hypothyroidism is a problem which afflicts many breeds of dog, but far and away most canine hypothyroidism is adult-onset and is an immune-mediated disorder associated with production of anti-thyroglobulin antibodies.

Congenital hypothyroidism is quite different. "Congenital" indicates that the hypothyroidism is present at or soon after birth rather than developing years later. Congenital hypothyroidism occurs in different forms in different breeds caused by various abnormalities of the hypothalamus, the pituitary gland, or the thyroid glands itself.

Myotonia Congenita ~ is an inherited condition characterized by delayed relaxation of skeletal muscle after voluntary contraction without associated symptoms of weakness or muscular dystrophy.

GM1 Gangliosidosis ~ Ganglioside storage diseases are defects of lysosomal hydrolase enzymes that result in accumulation of gangliosides (glycosphingolipids that are major constituents of plasma membranes in a variety of cells, especially neurons) and glycolipid substrates of these hydrolases within lysosomes of most neurons throughout the nervous system, including brain, spinal cord, and autonomic ganglia.

Hemophilia B ~ (factor IX deficiency, Christmas disease) Hemophilia is a bleeding disorder of varying severity that is due to a deficiency in specific clotting factors.

Canine Leucocyte Adhesion Deficiency (CLAD) ~ is a fatal immunodeficiency disease found in Irish Setters.

Progressive Retinal Atrophy (PRA) ~ The cells of the retina receive light stimuli from the external environment and transmit the information to the brain where it is interpreted to become vision. In progressive retinal atrophy (PRA), deterioration of the retinal cells causes blindness.

Narcolepsy ~ is an uncommon disorder that results in abnormal sleep tendencies (e.g. sudden onset of sleep), sleep paralysis, and cataplexy. One of the manifestations of narcolepsy is cataplexy which is characterized by a rapid onset of sleep, resulting in flaccid paralysis that lasts for a few seconds to a few minutes.

Muscular Dystrophy ~ The most common form of muscular dystrophy in dogs and humans is caused by mutations in the dystrophin gene.

Mucopolysaccharidosis type VII ~ is a lysosomal storage disease in which there is a buildup (storage) of mucopolysaccharides (glycosaminoglycans), due to the lack of the lysosomal enzyme acid hydrolase beta-glucuronidase

Thrombopathia ~ means a disorder of small blood cells called platelets or thrombocytes. Platelets play an important role at several stages of the body's response to any injury that causes bleeding. One function of platelets is to aggregate or "clump" at the site of blood vessel injury to form an initial plug. Platelets also facilitate blood clotting, in conjunction with the clotting factors, and release substances active in inflammation and tissue repair.

Thrombasthenic ~ In thrombasthenic thrombopathia, there is a reduction or absence of certain platelet membrane proteins that are necessary for normal platelet function.

Neonatal Encephalopathy (NEWS) ~ Neonatal encephalopathy with seizures (NEWS) is a previously undescribed autosomal recessive disease of standard poodle puppies. Affected puppies are small and weak at birth. Many die in their first week of life. Those surviving past 1 week develop ataxia, a whole-body tremor, and, by 4 to 6 weeks of age, severe generalized clonic-tonic seizures. None have survived to 7 weeks of age.

Glycogen Storage Disease Ia ~ also known as glycogenoses, is a rare inherited disorder with various types, all characterized by deficient or defective activity of the enzymes responsible for metabolizing glycogen in the body.

L-2-hydroxyglutaric aciduria ~ L-2-HGA affects the central nervous system, with clinical signs usually apparent between 6 months and one year (although they can appear later). Symptoms include epileptic seizures, "wobbly" gait, tremors, muscle stiffness as a result of exercise or excitement and altered behavior.

Multidrug Resistance in Cancer ~ Dogs with mutant MDR1 gene cannot remove some drugs out of the brain as normal dogs would, which may result in abnormal neurological signs.

Pyruvate Dehydrogenase Phosphatase 1 Deficiency ~ The disease is characterised by exercise intolerance and post-exercise collapse. There may also be neurological symptoms. Treatment of affected dogs with a high-fat, ketogenic, diet has been suggested

Pyruvate Kinase Deficiency ~ (PK) is an enzyme critical to the anaerobic glycolytic pathway of energy production in the erythrocyte. If erythrocytes are deficient in PK they are unable to sustain normal cell metabolism and hence are destroyed prematurely. This deficiency manifests as an hemolytic anemia of variable severity with a strong regenerative response.

Canine Multifocal Retinopathy ~ (CMR) is a recently identified recessively inherited eye disease known so far to affect the Mastiffs (English, Bullmastiff, French mastiff or Dogue de Bordeaux), Great Pyrenees and Coton de Tulear.


So just to be clear, this all can't be done for a $50 DNA fee?