I only use it on Mahina once or twice a week. I put a small amount on a toothbrush (less than I would actual toothpaste) and I brush. I probably use less than half a pea size amount.
I do brush her teeth EVERY day with regular toothpaste though.
The first few times she would rub her face and do little sneezes. She doesn't sneeze anymore but does rub her face... then again she does that after she eats, gets a treat, or her teeth brushed with regular toothpaste.