Hello, when you are wanting to breed, you must study and know what you are getting into. Know what the bloodlines are noted for that you are looking to use. Check out each female with your Vet to make sure that there is enough room to even have the puppies (before breeding!), this is especially necessary with any female close to or around four pounds. I, personally will not breed a female under four pounds of my own. I will use a tiny male to bring down the size of my puppies if smaller pups are needed/wanted. I, personally prefer breeding girls to be at least five pounds. The AKC standard starts at four pounds, which should be a guide line. I do hope that this will help you.