The form that he has, has no known cause.
We have done MULTIPLE tests on parasites, he is completely clean.
The GI/GU intern at the University of Missouri said it may have been caused from trauma to his colon when he was impacted at 6 weeks old.
Here is the form of colitis he has.
Lymphocytic-plasmacytic Inflammatory Bowel Disease
Canine lymphocytic-plasmacytic gastroenteritis(LP) is one disease in a group of idiopathic, chronic intestinal diseases collectively termed inflammatory bowel disease (IBD), and is considered to be the most common cause of chronic vomiting and diarrhea in dogs. LP gastroenteritis is characterized by a diffuse infiltration of lymnphocytes and plasma cells into the lamina propria of the stomach and/or the small intestine resulting in diffuse mucosal inflammation. Lymphocytic-plasmacytic is the most prevalent form of IBD. Other forms of IBD may be due to other cellular infiltrates (i.e. eosinophilic gastroenteritis, granulomatous enteritis, chronic histiocytic ulcerative colitis in Boxers).
The definitive cause and pathogenesis of this disease remains unknown. It is thought that an abnormal mucosal immune response to various environmental antigens, potentially dietary or parasitic in origin, results in a host hypersensitivity reaction that is responsible for the recruitment of inflammatory cells. Continued exposure to the antigen perpetuates the gastrointestinal inflammation. Subsequent damage results from the elaboration of cytokines, release of proteolytic and lysosomal enzymes, complement activation secondary to immune complex deposition, and the generation of oxygen free radicals. Delayed gastric emptying can then occur secondary to the inflammation. Hereditary factors may also influence the development of IBD. |