I am HIGHLY allergic to anything with fur or dander.. BUT i have found some products that work wonders.. There is a shampoo called AllerpetD you can wash your yorkie in. I bathe her every 2 weeks or as needed. It is supposed to help cut back almost all the dander. It is Ph balanced so it wont hurt your furbaby. I also vaccuum 3 times a week with a vaccuum that has a hepa filter. I also have a hepa filter running in the livingroom/ dinning room all the time ( thats where my dog is the most ). I know all this sounds like too much for just a visitor but its just some advice so if your bf's brother comes around often it wont be too bad on him. I completely agree about the hotel. I never stayed at friends houses too long that had animals bc i knew what would happen to me with my allergies. Even if i took a pill it was horrible, eyes watery, shallow breathing, itchy rash..lol so trust me i know how to prevent dander..also ( sorry i know it sounds like im just babbling now) i spray that febreez with allergen reducer in it throughout the house and on furniture and i wash all the blankets that come in contact with the dog like once a week.. Am i a maniac or what?! lol but my Marley is soooo worth it! Hope that helps and sorry for talking your ear off