I've left mine overnight but not often, i've probably only done it like twice and i have 3 so they have each other. I just leave them in one room and make sure there is nothing that can fall on them, they can chew on, and leave food and water and their pads/beds, etc.. If i only had one i would worry that she would get lonely so i would prob. sneak her into the hotel room if it were already booked. Rules..smules..lol jk |