I think it would be okay if you leave her at home but just make sure you have her in a section of your house and totally "dog proof" that section and your whole house. You should also have somebody come check on her every 3 hours at least to make sure she eats or uses the bathroom. Cause trust me.... if you know shes gonna be alone at home you'll get worried sick by the time it hits night time cause shes never been w/o you. Then the whole hotel stay might not end up so sweet after all because you wont' enjoy it. You'll be up worrying.

But if you have somebody you trust there watching her every so often you won't be as worried....
Just a thought...