This really has me thinking now, as both of mine have had trouble with hair loss - I so rarely use Frontline, as I said before, I do when we are traveling. I used it last winter when we were going to Florida & then they had hair loss last winter on their ears & nose - thought it was leather ear. Then went mths without any Frontline, as I treat it differently at home. But I used Frontline again late this summer & then again in November when I went south - again I began seeing hair loss --- I have not been able to figure out why. I even finally had a skin scraping done on both dogs last mth & the vet couldn't find anything wrong with them. I now highly suspect the Frontline.