I used Advantage Multi and Nolee would go crazy for a while. He would run in circles, plop suddenly get up, run in circles, plop and all over again for several hours. Discussed this with my vet and was told he was just aggravated because he could not get to it. Water would have the same effect. Well I changed to Resolution. He does run around a little and tries to rub his back, but only for a few minutes. I guess this is the wetness. It is a hundred times better than how he acted with the advantage multi.