[QuickSilver]

It could be separation anxiety, but not necessarily.

I think the easiest way to fix the room thing is to change it up a little bit. Put her in the room at times when you are NOT leaving, so the correlation is not as clear to her. Going into the room at irregular intervals should teach her that you will always come back. You may want to treat her upon your return also so she has something to look forward to.

Re: the crate, was it the right size? If she can pee in one corner and sleep in another, it's too big. I think you can change her feelings towards the crate if you go slow. Put nice blankets in it and some special treats she only gets in the crate. Since she's learned to dislike it, I would leave some treats in it and leave the door open. Let her enter and leave the crate of her own accord. Praise and treat her when she goes into the crate. Eventually once she's warmed up to it, you can start closing the door.

Super cute avatar, by the way! She looks like a very happy gal.