I would not continually put a drug on her like Advantage every 2 weeks.
If you were to put water on the same spot on her back, does she run around and get depressed? Or is it just with the Advantage? If it is just with the med, it is causing a problem (irritation at the very least) and I would never use it again. Have you tried Frontline Plus and don't bathe her for 2-4 days after applying it?
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