lepto shot has the most reactions of any and only dhpp given then 3 weeks later lepto if necessary in your area and 3 weeks later rabies -- and you can do parvo and distemper separate too if you ask your vet as that way you know what vaccine is causing the reaction if you do all separate -- i titer now for everything every 3 years like the vaccines and dhpp is a 3 year vaccine now. I do not do lepto as it only covers some strains not all so do not want to take the risk -- also only do bordatella intranasal never do shot as more reaction with the shot and if not around alot of dogs i would not do that either |