Perhaps a stupid question

, but can our little girls become hormonal? How old is Roxy?
OR perhaps she got into something and ate it? Outside? ...causing a tummy ache?
Lord knows puppies, dogs, HUMANS can have anxiety at anytime - but because her routine is pretty routine, it is like something was definitely wrong at the moment. Maybe an "accident' in her crate and the smell bothered her immensely, and she was plainly embarrassed?