Great thread!
We decide as a family every year on one organization that we will support through monthly donations and this year is the ASPCA (yep, Sarah McLachlan got to us

). Other than the one group we pick, I make small donations as the spirit hits me.

We support or have supported HSUS, PETA (fairly recent for me), WWF and our local favorite, Animal Rights Foundation of Florida (ARFF) that I also participate in events with. I'll be watching this thread for ideas.
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"If you have men who will exclude any of God’s creatures from the shelter of compassion and pity, you will have men who will deal likewise with their fellow men." — St. Francis of Assisi, 1181-1226