Talk to your vet about giving them a small dose of dramamine or a small dose of something that will sedate her. My mom's lab is so nervous and we gave her Benadryl on our last long car trip and she (for the first time ever) slept during the ride. She's 70 lbs., and I remember my mom and I laughing at the huge dose the vet told us to give her, but it doesn't affect them the same way it does us. She wasn't out cold, but relaxed enough to doze on the trip. Make sure she has a bone or toy to chew on in the carrier to keep her occupied. I would also sleep with her blanket (or a shirt) and put that in the carrier so something will smell familiar. I would also try to position her so that she can see you- it might help to calm her. Make sure she's used to and comfortable in which ever carrier you are using.
Good luck! |