While I haven't taken Bella and Chloe on a real vacation far from home, I have taken them with me on a 2 hour road trip to the other coast of Florida a couple of times. I stayed in a hotel and they don't seem to mind that at all and they love going with me in their stroller. They people watch, get some extra attention and a few extra treats. The one thing I have consistently noticed with Bella is that she always gets extremely grouchy after a nights stay away from home. She tries to fight Chloe over anything. She will try to attack if Chloe lays too close to her or walks by her too closely. She has tried to fight Chloe when they both wanted in my lap, which never happens at home. The only thing I can think of is that Bella must not sleep very well away from home. Just like a child, she must get grumpy and irritable from a lack of sleep. Also, she is used to napping all day while I am at work and she doesn't get naps on vacation so she must be really sleep deprived lol! Bella definitely needs her beauty sleep.