I know with her first pregnancy, her nipples started swelling, and she had a few accidents, that's when I figured it out. We had bred her to a male a girlfriend of mine had, but the pup died, he got stuck during birth, and I couldn't do anything...RIP.. I am going to watch her so close this time!!! I later found out that my friend's male was diagnosed with a pancreatic condition, that would've passed on. I guess God knew what he was doing !!