When I first got Lil' Miss Izzie, at 12 weeks old, I did use the plug in defuser that releases the homorne that is suppose to calm them and I also left a radio on for her in the kitchen (which was where her xpen is). It did seem to work for her as I had my neighbor checking during the day to see if she was crying and to call me at work if she was crying/barking. I also left her with plenty of safe toys to play with during the day and just recently bought the doggie day care from kong that dispenses a treat every 4-8 hrs....
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