Maybe you could start training him to feel comfortable in a vehicle. Take him for little road trips each day and make it a super positive experience for him. Bring treats and use positive reinforcement. Start increasing the amount of drive time each time and he will do better and better each time. Also, it would be a good idea to wear him out before getting on the bus so that he doesn't have too much energy during the ride.
I have not used sedatives to take my dogs on road trips. They usually sleep once we get on the interstate. When my yorkie was younger, he had a lot of anxiety associated with getting in the car, but I did what I described above, and he adjusted very well. He has no problems riding in a car now.
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