Talk about SEPERATION ANXIETY!!
You must have the "Incredible Hulkstress" on your hands. Maybe that should be her name! I understand why you got her at 2 years old.
Unfortunatly, I don't have any real advice for you. Except maybe some heavy duty training!!! Maybe a dog behaviorist can help or someone else here with some good know how. I have found it too be very informative here.
I have known people with larger dogs that were very destructive when they were away. But I never heard their solutions!
Sorry I couldn't help, but GOOD LUCK. (It looks like you will need it!)